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// For complete examples and data files, please go to https://github.com/groupdocs-watermark/GroupDocs.Watermark-for-.NET
using (DiagramDocument doc = Document.Load<DiagramDocument>(Utilities.MapSourceFilePath(FilePath)))
{
    DiagramShape shape = doc.Pages[0].Shapes[0];
    for (int i = shape.Hyperlinks.Count - 1; i >= 0; i--)
    {
        if (shape.Hyperlinks[i].Address.Contains("http://someurl.com"))
        {
            shape.Hyperlinks.RemoveAt(i);
        }
    }

    doc.Save();
}