function wpse188669_pre_get_posts( $query ) {
if (
! is_admin()
&& $query->is_main_query()
&& $query->is_search()
) {
$query->set( 'post_type', array( 'product' ) );
// set your parameters according to
// https://codex.wordpress.org/Class_Reference/WP_Query#Taxonomy_Parameters
$tax_query = array(
array(
// likely what you are after
'taxonomy' => 'product_cat',
'field' => 'slug',
'terms' => 'category-2',
'operator' => 'NOT IN',
),
);
$query->set( 'tax_query', $tax_query );
}
}
add_action( 'pre_get_posts', 'wpse188669_pre_get_posts' );