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# TLP with newer kernel (4.16+) tends to autosuspend USB bluetooth devices.
# To work this around, teak tlp settings (set USB_BLACKLIST_BTUSB=1)
$ nano /etc/default/tlp

(...)
# Bluetooth devices are excluded from USB autosuspend:
#   0=do not exclude, 1=exclude.
USB_BLACKLIST_BTUSB=1
(...)