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# we're in the http context here
map $http_upgrade $connection_upgrade {
  default upgrade;
  ''      close;
}

# the Meteor / Node.js app server
server {
  server_name yourdomain.com;
  access_log /etc/nginx/logs/yourapp.access;
  error_log /etc/nginx/logs/yourapp.error error;

  location / {
    proxy_pass http://localhost:3000;
    proxy_set_header X-Real-IP $remote_addr;  # http://wiki.nginx.org/HttpProxyModule
    proxy_set_header Host $host;  # pass the host header - http://wiki.nginx.org/HttpProxyModule#proxy_pass
    proxy_http_version 1.1;  # recommended with keepalive connections - http://nginx.org/en/docs/http/ngx_http_proxy_module.html#proxy_http_version
    # WebSocket proxying - from http://nginx.org/en/docs/http/websocket.html
    proxy_set_header Upgrade $http_upgrade;
    proxy_set_header Connection $connection_upgrade;
  }

}

Tener en cuenta que Meteor utiliza websockets por lo que hay que instalar Nginx >= 1.4

Referencia
http://www.meteorpedia.com/read/nginx