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<?
// Run once an hour, weekdays, from 8-5
$schedule->command('do:thing')->weekdays()->hourly()->when(function () {
    return date('H') >= 8 && date('H') <= 17;
});

// или 
$schedule->command('do:thing')->everyThirtyMinutes()->skip(function () {
    return app('SkipDetector')->shouldSkip();
});