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const string appKeyString = @"SOFTWARE\CompanyName";
RegistryKey appRootKey = Registry.CurrentUser.CreateSubKey(appKeyString);
RegistryKey configKey = appRootKey.CreateSubKey("KeyName");
configKey.SetValue("ValueName", "Value", RegistryValueKind.String);
configKey.Flush();

RegistryKey regKey = Registry.CurrentUser.OpenSubKey(@"SOFTWARE\CompanyName\KeyName", false);
String temp = (string)regKey.GetValue("ValueName");

if (string.IsNullOrEmpty(temp)) { temp = "default"; }