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$config = \Drupal::configFactory()->config('setting.file.name'); // ->config('module_name.settings');

// Delete config
\Drupal::configFactory()->getEditable('migrate_plus.migration.sigel_product_categories_de')->delete();

// Returns the configuration, with overrides:
$config->get('setting');


// configuration without overrides
$config->getOriginal('setting', FALSE);
 

// Returning mutable configuration, which is configuration that is editable, always returns without overrides
$config->getEditable('setting');


// Save config
$config->set('setting', 'value')->save();