Cacher is the code snippet organizer for pro developers

1password - Password mangager
3hub - Amazon s3 file manager
Adium - Instant messenger 
Arq - Amazon s3 backup
Air Server - Send your iPhone/iPad screen to your mac screen for demos
Alfred - Launch bar app (must have)
Base - Sqlite db viewer
Caffeine - Keeps computer awake
Charles - Web debugging proxy 
Cornerstone - SVN client
Cyberduck - FTP client (free)
Delibar - Delicious bookmarking menu item
DiskWave - Monitor hdd space
Dropbox - Cloud storage
Echofon - Twitter Client
Evernote - Note taking
Facebook Notifications - Menu bar app
Facebook (Fluid app) - Fluid instance for Facebook 
Fantastical - Calendar app
Forklift - FTP client (paid)
Fluid - Create site specific browsers
Flux - Change screen color night to be easier on eyes
Gabble - Yammer client
Google Chrome
Isolator - Blur background apps, focus on one
iStat Menus - Monitor computer resources
iTerm2 - Better terminal
iVI - Video conversion
iA Writer - Cross iDevice note taking app
Name Mangler - Batch file renamer
Quicksilver/Alfred - App launcher, just switched to Alfred
Reeder - Rss Reader
Sequel Pro - SQL DB viewer
Skype
Sparrow - Email client
Textmate - Text editor
Things - Todo list 
Transmission - Bittorrent client
UnRarX - RAR archive extractor
VLC - Video player

Maybe Not This Time Pile:
Firefox
Ecoute - Lightweight iTunes alternative
Microsoft Office
Camouflage - Hide desktop icons


Suggestions
Homebrew - Install unix tools http://mxcl.github.com/homebrew/ (from @wolfeidau)