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@receiver(pre_save, sender=MyModel)
def do_something_if_changed(sender, instance, **kwargs):
    try:
        obj = sender.objects.get(pk=instance.pk)
    except sender.DoesNotExist:
        pass # Object is new, so field hasn't technically changed, but you may want to do something else here.
    else:
        if not obj.some_field == instance.some_field: # Field has changed
            # do something